How SARS-CoV-2 Damages the Kidneys

Cartoon image of damage to the kidneys. getty Kidney complications are some of the most common and severe symptoms associated with Covid-19. Estimates show that 30% of people hospitalized for severe infection and 50% of those that are later admitted to intensive care units experience some injury to the kidneys. Even previously healthy people with … Read more

Protection against SARS-CoV-2 highest after infection-acquired immunity boosted with vaccination in health care workers

1. SARS-CoV-2 infection-acquired immunity waned after 1 year, but immune protection remained high beyond 1 year in those boosted with vaccination. Evidence Rating Level: 2 (Good) Study Rundown: The effectiveness and duration of immune protection following SARS-CoV-2 vaccination or infection remains contested and pertinent to ongoing vaccination strategies. In this prospective study named the SARS-CoV-2 … Read more

Researchers investigate IgG antibodies against Mtb proteins in an Asian elephant cured of tuberculosis

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb); the leading cause of human death due to a single pathogen before the emergence of SARS-CoV-2. In elephants, the infections and deaths with TB have been reported worldwide, and elephant-to-human transmission has also been reported. Therefore, elephant TB is a concern for both conservation … Read more

Age-specific variation of asymptomatic COVID-19 infections

In a recent study posted to the medRxiv* preprint server, researchers evaluated asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection according to age. Study: Asymptomatic SARS-CoV-2 infection by age: A systematic review and meta-analysis. Image Credit: Andrii Vodolazhskyi / Shutterstock Asymptomatic coronavirus disease 2019 (COVID-19) infections have been a concerning subject in the design … Read more

The study investigates the cause of lymphopenia as seen in COVID-19 patients

In a recent study posted to the Research Square* preprint server, researchers explored the underlying mechanism resulting in thymic atrophy and subsequent lymphopenia in coronavirus disease 2019 (COVID-19) patients. Study: SARS-CoV-2 and its variants, but not Omicron, induces severe thymic atrophy and impaired T cell development. Image Credit: erhanyelekci / Shutterstock Previous studies have reported … Read more

The potential impact of oral vaccination against COVID-19 is a transmission to naïve individuals studied in a hamster infection model

A recent article published in Science Translational Medicine demonstrated that mucosally delivered adenovirus type 5 (Ad5) -based coronavirus disease 2019 (COVID-19) vaccination minimized COVID-19 transmission and severity. Study: Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model. Image Credit: sdecoret / Shutterstock Background The currently approved … Read more

Diagnostic performance of monocyte distribution width and other leukocyte parameters for SARS-CoV-2 and influenza infection

In a recent study posted to the Research Square* preprint server, researchers used a novel diagnostic screen, monocyte distribution width (MDW) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza infection. Study: Monocyte Distribution Width as a Pragmatic Diagnostic Screen for SARS-CoV-2 and Influenza Infection. Image Credit: Corona Borealis Studio / Shutterstock Background MDW, … Read more

Effectiveness of BNT162b2 third dose against Omicron-associated severe disease

In a recent study posted to the medRxiv* preprint server, researchers analyzed the effectiveness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BNT162b2 third vaccine dose against SARS-CoV-2 Omicron-induced severe infection nearly seven months post-vaccination. Study: Protection against omicron severe disease 0-7 months after BNT162b2 booster. Image Credit: peterschreiber.media/Shutterstock Background Following an increase in … Read more

Evidence of croup associated with SARS-CoV-2

Croup, inflammation of the subglottic upper airway mucosa manifest as respiratory distress airflow obstruction in children. In addition, it is associated with epithelial-level edema, and now emergency department (ED) administrations occur due to an acute viral infection. Study: Croup Associated With SARS-CoV-2: Pediatric Laryngotracheitis During the Omicron Surge. Image Credit: rumruay / Shutterstock The frequency … Read more

Approximately 13% of hospitalized COVID patients have severe neurologic symptoms

It has been established that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes dysfunction throughout the body, including the nervous system. Even in patients with moderate acute disease, neurological symptoms may be encountered. In some cases, these manifestations may persist due to long-haul coronavirus disease, also known as long-COVID. Case series, single health system … Read more