New genetic markers could improve early detection of drug-resistant tuberculosis

To many, tuberculosis (TB) may seem like a disease from a bygone era. But it still claims more than one million lives every year. And the problem is growing worse as Mycobacterium tuberculosisthe pathogen that causes TB, continues to evolve resistance to the antibiotics used to treat the disease. Now, researchers at San Diego State … Read more

Age-specific variation of asymptomatic COVID-19 infections

In a recent study posted to the medRxiv* preprint server, researchers evaluated asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection according to age. Study: Asymptomatic SARS-CoV-2 infection by age: A systematic review and meta-analysis. Image Credit: Andrii Vodolazhskyi / Shutterstock Asymptomatic coronavirus disease 2019 (COVID-19) infections have been a concerning subject in the design … Read more

The study investigates the cause of lymphopenia as seen in COVID-19 patients

In a recent study posted to the Research Square* preprint server, researchers explored the underlying mechanism resulting in thymic atrophy and subsequent lymphopenia in coronavirus disease 2019 (COVID-19) patients. Study: SARS-CoV-2 and its variants, but not Omicron, induces severe thymic atrophy and impaired T cell development. Image Credit: erhanyelekci / Shutterstock Previous studies have reported … Read more

The potential impact of oral vaccination against COVID-19 is a transmission to naïve individuals studied in a hamster infection model

A recent article published in Science Translational Medicine demonstrated that mucosally delivered adenovirus type 5 (Ad5) -based coronavirus disease 2019 (COVID-19) vaccination minimized COVID-19 transmission and severity. Study: Adenovirus type 5 SARS-CoV-2 vaccines delivered orally or intranasally reduced disease severity and transmission in a hamster model. Image Credit: sdecoret / Shutterstock Background The currently approved … Read more

Diagnostic performance of monocyte distribution width and other leukocyte parameters for SARS-CoV-2 and influenza infection

In a recent study posted to the Research Square* preprint server, researchers used a novel diagnostic screen, monocyte distribution width (MDW) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza infection. Study: Monocyte Distribution Width as a Pragmatic Diagnostic Screen for SARS-CoV-2 and Influenza Infection. Image Credit: Corona Borealis Studio / Shutterstock Background MDW, … Read more

Effectiveness of BNT162b2 third dose against Omicron-associated severe disease

In a recent study posted to the medRxiv* preprint server, researchers analyzed the effectiveness of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BNT162b2 third vaccine dose against SARS-CoV-2 Omicron-induced severe infection nearly seven months post-vaccination. Study: Protection against omicron severe disease 0-7 months after BNT162b2 booster. Image Credit: peterschreiber.media/Shutterstock Background Following an increase in … Read more

Evidence of croup associated with SARS-CoV-2

Croup, inflammation of the subglottic upper airway mucosa manifest as respiratory distress airflow obstruction in children. In addition, it is associated with epithelial-level edema, and now emergency department (ED) administrations occur due to an acute viral infection. Study: Croup Associated With SARS-CoV-2: Pediatric Laryngotracheitis During the Omicron Surge. Image Credit: rumruay / Shutterstock The frequency … Read more

Approximately 13% of hospitalized COVID patients have severe neurologic symptoms

It has been established that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes dysfunction throughout the body, including the nervous system. Even in patients with moderate acute disease, neurological symptoms may be encountered. In some cases, these manifestations may persist due to long-haul coronavirus disease, also known as long-COVID. Case series, single health system … Read more

ZF2001 vaccine safe and effective against symptomatic and severe-to-critical COVID

Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), scientists and policymakers have continued to work relentlessly to control the pandemic. The availability of multiple COVID-19 vaccines, developed on different platforms, is considered a powerful tool in the containment of the pandemic. Background Previous studies … Read more

Infection with SARS-CoV-2 results in antibodies against common colds

Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provides immunity against seasonal human coronaviruses (HCoVs). Whether SARS-CoV-2 infection causes a boost in the preexisting HCoV-specific antibodies or elicits cross-reactive β-CoV antibodies that target conserved epitopes is unknown. A study published in the journal Science Advances uses electron microscopy-based polyclonal epitope mapping (EMPEM) methodology … Read more