T cell behavior determines the success of immunotherapy

Immunotherapy unleashes the power of the immune system to fight cancer, but for some patients, immunotherapy doesn’t work. New research from Weill Cornell Medicine investigators may help explain why. When immune cells called T lymphocytes infiltrate malignant tumors, the genetic program of those T cells, and the developmental pathway they then follow, may affect their … Read more

Protection against SARS-CoV-2 highest after infection-acquired immunity boosted with vaccination in health care workers

1. SARS-CoV-2 infection-acquired immunity waned after 1 year, but immune protection remained high beyond 1 year in those boosted with vaccination. Evidence Rating Level: 2 (Good) Study Rundown: The effectiveness and duration of immune protection following SARS-CoV-2 vaccination or infection remains contested and pertinent to ongoing vaccination strategies. In this prospective study named the SARS-CoV-2 … Read more

Researchers investigate IgG antibodies against Mtb proteins in an Asian elephant cured of tuberculosis

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb); the leading cause of human death due to a single pathogen before the emergence of SARS-CoV-2. In elephants, the infections and deaths with TB have been reported worldwide, and elephant-to-human transmission has also been reported. Therefore, elephant TB is a concern for both conservation … Read more

Age-specific variation of asymptomatic COVID-19 infections

In a recent study posted to the medRxiv* preprint server, researchers evaluated asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection according to age. Study: Asymptomatic SARS-CoV-2 infection by age: A systematic review and meta-analysis. Image Credit: Andrii Vodolazhskyi / Shutterstock Asymptomatic coronavirus disease 2019 (COVID-19) infections have been a concerning subject in the design … Read more

National addiction treatment locator has outdated data and other critical flaws

At a psychiatric hospital in Michigan, Dr. Cara Poland’s patients were handed a sheet of paper to find follow-up care. The hospital had entered local ZIP codes on a website – run by the nation’s top substance use and mental health agency – and printed the resulting list of providers for patients to call. But … Read more

The study investigates the cause of lymphopenia as seen in COVID-19 patients

In a recent study posted to the Research Square* preprint server, researchers explored the underlying mechanism resulting in thymic atrophy and subsequent lymphopenia in coronavirus disease 2019 (COVID-19) patients. Study: SARS-CoV-2 and its variants, but not Omicron, induces severe thymic atrophy and impaired T cell development. Image Credit: erhanyelekci / Shutterstock Previous studies have reported … Read more